USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P01111 USC-OGP 2-DE database:  P01111 P01111 General information about the entry View entry in simple text format Entry name RASN_HUMAN Primary accession number P01111 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=GTPase NRas; AltName: Full=Transforming protein N-Ras; Flags: Precursor;. Gene name Name=NRAS Synonyms=HRAS1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0220: pI=4.90; Mw=20827 SPOT OGP-0225: pI=4.67; Mw=20393 Cross-references UniProtKB/Swiss-Prot P01111; RASN_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name RASN_HUMAN Primary accession number P01111 Secondary accession number(s) Q14971 Q15104 Q15282 Sequence was last modified on  July 21, 1986 (version 1) Annotations were last modified on  March 15, 2017 (version 199) Name and origin of the protein Description RecName: Full=GTPase NRas; AltName: Full=Transforming protein N-Ras; Flags: Precursor; Gene name Name=NRAS Synonyms=HRAS1 Encoded on Name=NRAS; Synonyms=HRAS1 Keywords 3D-structure; Acetylation; Cell membrane; Complete proteome; Disease mutation; Golgi apparatus; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Palmitate; Prenylation; Proto-oncogene; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X02751; CAA26529.1; -; mRNA EMBL X00642; CAA25269.1; -; Genomic_DNA EMBL X00643; CAA25270.1; -; Genomic_DNA EMBL X00644; CAA25271.1; -; Genomic_DNA EMBL X00645; CAA25272.1; -; Genomic_DNA EMBL L00043; AAA60255.1; -; Genomic_DNA EMBL L00040; AAA60255.1; JOINED; Genomic_DNA EMBL L00041; AAA60255.1; JOINED; Genomic_DNA EMBL L00042; AAA60255.1; JOINED; Genomic_DNA EMBL AF493919; AAM12633.1; -; mRNA EMBL AY428630; AAQ94397.1; -; Genomic_DNA EMBL BC005219; AAH05219.1; -; mRNA EMBL M25898; AAA36548.1; -; Genomic_DNA EMBL X53291; CAA37384.1; -; Genomic_DNA EMBL X53292; CAA37384.1; JOINED; Genomic_DNA EMBL K03211; AAA36556.1; -; Genomic_DNA EMBL M10055; AAA36556.1; JOINED; Genomic_DNA EMBL X05565; CAA29079.1; -; Genomic_DNA EMBL X07440; CAA30320.1; -; Genomic_DNA CCDS CCDS877.1; -; . PIR A90839; TVHURA; . PIR I38149; I38149; . RefSeq NP_002515.1; NM_002524.4; . UniGene Hs.486502; -; . PDB 2N9C; NMR; -; A=1-17 PDB 3CON; X-ray; 1.65 A; A=1-172 PDBsum 2N9C; -; . PDBsum 3CON; -; . ProteinModelPortal P01111; -; . SMR P01111; -; . BioGrid 110952; 33; . DIP DIP-1058N; -; . IntAct P01111; 33; . MINT MINT-131535; -; . STRING 9606.ENSP00000358548; -; . BindingDB P01111; -; . ChEMBL CHEMBL2079845; -; . GuidetoPHARMACOLOGY 2823; -; . iPTMnet P01111; -; . PhosphoSitePlus P01111; -; . SwissPalm P01111; -; . BioMuta NRAS; -; . DMDM 131883; -; . OGP P01111; -; . EPD P01111; -; . PaxDb P01111; -; . PeptideAtlas P01111; -; . PRIDE P01111; -; . DNASU 4893; -; . Ensembl ENST00000369535; ENSP00000358548; ENSG00000213281; . GeneID 4893; -; . KEGG hsa:4893; -; . CTD 4893; -; . DisGeNET 4893; -; . GeneCards NRAS; -; . GeneReviews NRAS; -; . HGNC HGNC:7989; NRAS; . HPA CAB010157; -; . HPA HPA049830; -; . MalaCards NRAS; -; . MIM 137550; phenotype; . MIM 162900; phenotype; . MIM 164790; gene; . MIM 188470; phenotype; . MIM 249400; phenotype; . MIM 607785; phenotype; . MIM 613224; phenotype; . MIM 614470; phenotype; . neXtProt NX_P01111; -; . OpenTargets ENSG00000213281; -; . Orphanet 86834; Juvenile myelomonocytic leukemia; . Orphanet 626; Large congenital melanocytic nevus; . Orphanet 648; Noonan syndrome; . Orphanet 268114; RAS-associated autoimmune leukoproliferative disease; . PharmGKB PA31768; -; . eggNOG KOG0395; Eukaryota; . eggNOG COG1100; LUCA; . GeneTree ENSGT00860000133672; -; . HOGENOM HOG000233973; -; . HOVERGEN HBG009351; -; . InParanoid P01111; -; . KO K07828; -; . OMA RSSYDEI; -; . OrthoDB EOG091G0UAU; -; . PhylomeDB P01111; -; . TreeFam TF312796; -; . Reactome R-HSA-112412; SOS-mediated signalling; . Reactome R-HSA-1169092; Activation of RAS in B cells; . Reactome R-HSA-1236382; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; . Reactome R-HSA-1250196; SHC1 events in ERBB2 signaling; . Reactome R-HSA-1250347; SHC1 events in ERBB4 signaling; . Reactome R-HSA-1433557; Signaling by SCF-KIT; . Reactome R-HSA-167044; Signalling to RAS; . Reactome R-HSA-171007; p38MAPK events; . Reactome R-HSA-179812; GRB2 events in EGFR signaling; . Reactome R-HSA-180336; SHC1 events in EGFR signaling; . Reactome R-HSA-186763; Downstream signal transduction; . Reactome R-HSA-1963640; GRB2 events in ERBB2 signaling; . Reactome R-HSA-210993; Tie2 Signaling; . Reactome R-HSA-2179392; EGFR Transactivation by Gastrin; . Reactome R-HSA-2424491; DAP12 signaling; . Reactome R-HSA-2428933; SHC-related events triggered by IGF1R; . Reactome R-HSA-2871796; FCERI mediated MAPK activation; . Reactome R-HSA-375165; NCAM signaling for neurite out-growth; . Reactome R-HSA-5218921; VEGFR2 mediated cell proliferation; . Reactome R-HSA-5621575; CD209 (DC-SIGN) signaling; . Reactome R-HSA-5637810; Constitutive Signaling by EGFRvIII; . Reactome R-HSA-5654688; SHC-mediated cascade:FGFR1; . Reactome R-HSA-5654693; FRS-mediated FGFR1 signaling; . Reactome R-HSA-5654699; SHC-mediated cascade:FGFR2; . Reactome R-HSA-5654700; FRS-mediated FGFR2 signaling; . Reactome R-HSA-5654704; SHC-mediated cascade:FGFR3; . Reactome R-HSA-5654706; FRS-mediated FGFR3 signaling; . Reactome R-HSA-5654712; FRS-mediated FGFR4 signaling; . Reactome R-HSA-5654719; SHC-mediated cascade:FGFR4; . Reactome R-HSA-5655253; Signaling by FGFR2 in disease; . Reactome R-HSA-5655291; Signaling by FGFR4 in disease; . Reactome R-HSA-5655302; Signaling by FGFR1 in disease; . Reactome R-HSA-5658442; Regulation of RAS by GAPs; . Reactome R-HSA-5673000; RAF activation; . Reactome R-HSA-5673001; RAF/MAP kinase cascade; . Reactome R-HSA-5674135; MAP2K and MAPK activation; . Reactome R-HSA-5675221; Negative regulation of MAPK pathway; . Reactome R-HSA-6798695; Neutrophil degranulation; . Reactome R-HSA-6802946; Signaling by moderate kinase activity BRAF mutants; . Reactome R-HSA-6802948; Signaling by high-kinase activity BRAF mutants; . Reactome R-HSA-6802949; Signaling by RAS mutants; . Reactome R-HSA-6802952; Signaling by BRAF and RAF fusions; . Reactome R-HSA-6802953; RAS signaling downstream of NF1 loss-of-function variants; . Reactome R-HSA-6802955; Paradoxical activation of RAF signaling by kinase inactive BRAF; . Reactome R-HSA-74751; Insulin receptor signalling cascade; . Reactome R-HSA-8849471; PTK6 Regulates RHO GTPases; RAS GTPase and MAP kinases; . Reactome R-HSA-8851805; MET activates RAS signaling; . Reactome R-HSA-8853334; Signaling by FGFR3 fusions in cancer; . Reactome R-HSA-8853338; Signaling by FGFR3 point mutants in cancer; . SignaLink P01111; -; . SIGNOR P01111; -; . ChiTaRS NRAS; human; . EvolutionaryTrace P01111; -; . GeneWiki Neuroblastoma_RAS_viral_oncogene_homolog; -; . GenomeRNAi 4893; -; . PRO PR:P01111; -; . Proteomes UP000005640; Chromosome 1; . Bgee ENSG00000213281; -; . CleanEx HS_NRAS; -; . ExpressionAtlas P01111; baseline and differential; . Genevisible P01111; HS; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005794; C:Golgi apparatus; IDA:CACAO; . GO GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0005886; C:plasma membrane; TAS:Reactome; . GO GO:0070821; C:tertiary granule membrane; TAS:Reactome; . GO GO:0005525; F:GTP binding; IEA:UniProtKB-KW; . GO GO:0032403; F:protein complex binding; IDA:MGI; . GO GO:0007411; P:axon guidance; TAS:Reactome; . GO GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome; . GO GO:0038128; P:ERBB2 signaling pathway; TAS:Reactome; . GO GO:0072600; P:establishment of protein localization to Golgi; IMP:CACAO; . GO GO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome; . GO GO:0050900; P:leukocyte migration; TAS:Reactome; . GO GO:0000165; P:MAPK cascade; TAS:Reactome; . GO GO:0043312; P:neutrophil degranulation; TAS:Reactome; . GO GO:0007265; P:Ras protein signal transduction; TAS:Reactome; . GO GO:0002223; P:stimulatory C-type lectin receptor signaling pathway; TAS:Reactome; . Gene3D 3.40.50.300; -; 1; . InterPro IPR027417; P-loop_NTPase; . InterPro IPR005225; Small_GTP-bd_dom; . InterPro IPR001806; Small_GTPase; . InterPro IPR020849; Small_GTPase_Ras; . PANTHER PTHR24070; PTHR24070; 1; . Pfam PF00071; Ras; 1; . SUPFAM SSF52540; SSF52540; 1; . TIGRFAMs TIGR00231; small_GTP; 1; . PROSITE PS51421; RAS; 1; .

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